Imagine a world in which Alchemy is not only possible, but used frequently. Alchemy, though, is a science, and with all sciences there are laws that must be followed. Welcome to the anime, Full Metal Alchemist. The story begins about two brothers, Alphonse and Edward Elric. Ever since they were young they had practiced the science of alchemy. You follow their journey of being alchemists and their quest to regain that which they have lost.
Their father was a well recognized alchemist, which is probably where their knack for it comes from. However, when they were young their father left, and they remained in the care of their mother. One day their mother died, and in their innocence and ignorance, they attempted what was forbidden, human alchemy.
What happened next, they were obviously not prepared for, and in the aftermath the brothers lost more than just their mother. In the freak accident Alphonse loses his body, and in a moment of panic Edward ties his brother's soul to a piece of armor. Edward himself loses an arm and a leg, a costly reminder of what has happened.
The story begins and details the brother's journey to find a alchemy amplifier so that they may return to their normal bodies.